Dr. Senthilkumar Rajagopal Associate Professor

School of Applied Sciences

senthilkumar.r@reva.edu.in

Specialization

Neuroscience / Cell Biology

Areas Of Interest

GPCR signalling in Inflammation and Calcium channels in chronic pain

Qualification

M.Sc., PhD, Post doc

Teaching Experience

Academic – 22 years

Awards & Recognition

Awards & Recognitions:

2025 Among World Top 2% Scientists by Stanford University with Elsevier Researcher Hub
2025 Abstract Reviewer – ABRCMS Travel Award
2025 Session Chair – 11th International RENPER Conference, REVA University
2025 Reviewer – ICBEB 2025, Japan
2025 Organizing Committee Member – 7th European Congress on Applied Microbiology, Rome
2025 Scientific Committee Member – International Conference on Food Science & Nutrition, Oxford UK
2025 Guide – 48th KSCST Student Project Program 2024-25
2025 National Advisory Member – 2nd IC-RIBCCS, Manipal University College, Malaysia
2025 Guest Speaker – 6th Asian Conference on Science, Technology & Medicine, Dubai
2025 Member – Asian Council of Science Editors
2025 Guest Speaker – 1st International Conference on Biological Sciences for a Sustainable Future, Indrashil University, Gujarat
2024 Abstract Reviewer – ABRCMS Travel Award, USA
2024 Advisor – CropNow Startup, REVA-NEST, REVA University
2024 Keynote Speaker – ICIT 2024, INTI International University, Malaysia
2024 Reviewer – ICBEB 2024, Singapore
2024 Organizing Committee Member – Catalyst Conference by FASEB & REVA University
2024 Organizing Committee Member – World Environmental Day Event with Ministry of Earth Sciences
2024 Session Chair – Viksit Bharat@2047 Vedant Knowledge System, Gujarat
2024 I-STEM District Ambassador – Bengaluru
2024 Panelist – “Digital Catalogue & P4 Tech” at IISc-iSTEM
2023 University Research Fellow – INTI International University, Malaysia
2023 Subject Matter Expert – Office of Principal Scientific Adviser to PMO, GoI
2023 Talk to Expert – Electrophysiology Hub for Neuronal Sciences, IISc-iSTEM
2022 Organizing Committee Member – INSA National Conference at REVA University
2022 Quality Leader – Andhra Pradesh State Higher Education Council
2021 Session chair – Life Sciences. Connecting ASIA (Academy Society & Industry Alliance) & AMC (ASIA Multidisciplinary Conference), Malaysia. April 9-10 2021
2021 Best Oral Presentation Award -2nd International Conference on Environmental, Agricultural, Chemical and Biological Sciences (ICEACB-2021)
2021 Best Researcher Award – Voice of Indian Concern for the Environment (VOICE)
2021 Best Oral Presentation Award - IBTAFP – 2021
2020 Chair [19-12-20] 6th ASIA International Conference (AIC 2020), Malaysia
2020 Best Oral Presentation Award, International Virtual Conference on Biotechnology, Bioinformatics & Biomedicine (IECBBB-2020), AIMST University, Kedah, (Malaysia), August 24-26 2020.
2020 Mentor & Speaker, Young Science Leadership Program, Run by Indian Academic of Science, Bangaloru, INDIA
2020 Ramalingaswami Re-entry Project is selected for Socio-economic impact of Assessment and Analysis project by Spectrum Planning PVT ltd commissioned with DBT, MST, INDIA.
2020 Technical Committee Member – 5th international conference on Inflammation Research, China.
2020 Resource Person – International Virtual conference on “Business Developmental skills in Life Science”, Alagappa University, TN, INDIA
2020 Scientific Committee Member – 22nd International Conference on Agricultural and Food Science (ICAFS 2020), Istanbul, Turkey
2020 Resource Person – International conference on “current trends in biotechnology”, Naryana Guru College of Arts and Science, Coimbatore, TN, INDIA
2019 Chair Person, NAAC sponsored Two day national symposium on Improvement of quality issues in higher education. The role of IQAC. Veerashaiva College, Ballari, KA.
2019 Guide [FL3677] for Joint Summer Research Program: The Indian National Science Academy in New Delhi, The National Academy of Sciences, Allahabad, India, Indian Academy of Sciences, Bengaluru
2019 Organizing Committee Member – International Conference on Neuroscience and Neurosurgery. Theme: Exploring Breakthroughs in Neuroscience and Neurosurgery. Aug 12-14 2019, Rome, ITLAY
2018 Scientific Committee Member – 22nd International Conference on Agricultural and Food Science (ICAFS2018), Istanbul, Turkey
2018 Outstanding Scientist in Biochemistry by Venus International Research foundation, Chennai, TN, INDIA
2018 Program Committee Member- Asian Conference on Science, Technology and Medicine (ACSTM-2019), 3rd Conference, Dubai, UAE
2018-2020 DBT representative in the Institutional Bio safety Committee of Genomix CARL Pvt Ltd., (Genomix-C), Pulivendula, AP
2017 Advisory Board & Scientific Chair person - World Congress on Genetics Genomics and Personalized Medicine, IISc, Bangaloru, India
2015 Leading Professional of the World – International Biographical Center, Cambridge UK
2012 Keystone Symposium, Canada – Travel Grant

International Visits: 3

Vidwan ID/Profile URL

https://vidwan.inflibnet.ac.in/profile/229819

Scopus ID/Google Scholar ID

https://www.scopus.com/authid/detail.uri?authorId=14040433300

Funded Project (amount sanctioned)

Sl. No	Name of the Principal Investigator/Co-Investigator	Name of the Funding Agency	Type (Government/Non-Government)	Department	Year of Award	Funds Provided (INR in lakhs)	Year of Sanction	Status
1	Dr. R. Senthilkumar	DBT	Government	Biotechnology	2013	115.75	2013	Completed
2	Dr. R. Senthilkumar	INSA/NASI/IASc	Non-Government	Biotechnology	2019	0.25	2019	Completed
3	Dr. R. Senthilkumar	INSA/NASI/IASc	Non-Government	Biotechnology	2022	0.25	2022	Completed
4	Dr. R. Senthilkumar	REVA University (Seed Fund)	Non-Government	Biotechnology	2023	6.50	2023	Ongoing
5	Dr. R. Senthilkumar	INSA-NASI-IASc (Summer Research Fellowship)	Non-Government	Biotechnology	2024	0.1875	2024	Completed
6	Dr. R. Senthilkumar	DBT – Ramalingaswami Re-entry Fellowship	Government	Biotechnology	2013	67.50	2013	Completed

PhDs Guided/PhDs Guiding

Publications In Refereed Journals

Key Publications (Only Q1 & Q2 rated):

Tikam Chand Dakal, Joice K. Joseph, Deepika, Pawan Maurya, Narendra kumar Sharma, Senthilkumar Rajagopal. Comprehensive Report on Biochemical, Pharmacological, and Pharmacokinetic Properties of Tool Compounds Relevant to Human Pathologies. RSC-Pharmaceutics. 2025; 2: 480-489. Impact factor: 4.2: https://doi.org/10.1039/D4PM00331D. Q1
Reya Rene Philip, Ravi Bhushan, Priyanka Vijay Sonar, Senthilkumar Rajagopal, Abhishek Kumar, Tikam Chand Dakal. Genetic and Epigenetic Regulation of Non-coding RNAs: Implications in Cancer Metastasis, Stemness and Drug Resistance. Pathology - Research and Practice. 2025, 266; 155278. Impact factor: 3.2: https://doi.org/10.1016/j.prp.2024.155728. Q2
Rajagopal S, Kumar DP and Arul AB (2022) Editorial: Regulatory action of calcium channels in pain pathway. Front Cell Neurosci 16:928457.1-3. Impact factor: 6.147: https://doi.org/10.3389/fncel.2022.928457. Q1
Meerza Abdul Razak, B. Viswanath, P. S. Begum, Senthilkumar Rajagopal. Multifarious beneficial effect of non-essential amino acid, glycine: a Review. Special Issue on Dietary Supplements/Antioxidants: Impact on Redox Status in Brain Diseases. Oxidative Medicine and Cellular Longevity. Vol.2022: Article ID 1716701.1-8. Impact factor: 3.614: doi: 10.1155/2017/1716701. Q1
Senthilkumar Rajagopal, Brittney K. Burton, Blanche L. Fields, EI Io and Ganesan L. Kamatchi. Stimulatory and Inhibitory effects of PKC isozymes are mediated by Serine/Threonine PKC Sites of the Cav2.31subunits. Archives of Biochemistry and Biophysics; 2017; 621: 24-30. Impact factor: 3.391: https://doi.org/10.1016/j.abb.2017.04.002. Q1
Senthilkumar Rajagopal, Ancy D. Nalli, Divya P. Kumar, Sayak Bhattacharya, Wehuihu, Sunila Mahavadi, John R Grider, Karnam S Murthy. Cytokine-Induced S-Nitrosylation of Soluble Guanylyl Cyclase and Expression of Phosphodiesterase 1A Contribute to Dysfunction of Longitudinal Smooth Muscle Relaxation. Journal of Pharmacology and Experimental Therapeutics; 2015; 352(3):509-518. Impact factor: 3.8: DOI: 10.1124/jpet.114.221929. Q1
Senthilkumar Rajagopal, Blanche L. Fields and Ganesan L. Kamatchi. Contribution of Protein Kinase C Isozyme in the Stimulation of Insulin Secretion by the Inhibition of Cavβ subunits. Endocrine; 2014; 47(2):463-471. Impact factor: 2.9: doi: 10.1007/s12020-013-0149-y Q1
Vanitha Bala, Senthilkumar Rajagopal, Divya P. Kumar, Sunila Mahavadi, Ruizhe Zhou, Zachary L. Bradley, Nigel W Bunnett, Carlos U. Corvera, Johan Auwerx, John R. Grider, Arun J. Sanyal, Karnam S. Murthy. Hydrogen Sulfide (H2S) Inhibits Bile Acid Receptor TGR5-Mediated GLP-1 Release from Enteroendrocrine Cells: Possible Involvement of H2S in Altered Glucose Metabolism in Diabetes. Gastroenterology. 2012; 142 (5): S-50. Impact factor: 25.1: https://doi.org/10.3389/fphys.2014.00420. Q1
Fang H, Patanavanich S, Senthilkumar Rajagopal, Yi X, Gill MS, Sando JJ, Kamatchi GL. Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phorbol-12-myristate, 13-acetate. The Journal of Biological Chemistry. 2006; 281(29): 20011-7. Impact factor: 3.9: DOI: 10.1074/jbc.M601776200. Q1
R. Senthilkumar, M. Ponmozhi, P. Viswanathan, N. Nalini. Antioxidant activity of Cassia auriculata in rats with alcoholic liver injury. The Journal of Nutritional Biochemistry. 2003; 14(8): 452-458. Impact factor: 4.9: DOI: 10.1016/s0955-2863(03)00053-6. Q1
Nitya Mankal, Krishna Badrakiya, Angela Mayanglambam, Aishani Chakraborty, Senthilkumar Rajagopal. Exploring the role of packaging material in preserving antioxidant activities and stress gene stability of refrigerated foods. Food Nutrition Chemistry. 2025; 3(4):532. Impact factor: 1.21. Q4
Ashmitha P Reddy, Nitya Mankal, Md Enamul Hoque, Senthilkumar Rajagopal. Microalgae-Based Urban Wastewater Treatment - Recent Advances and Future Prospects. Journal of Water Management Modelling. 2025.33:C565. Impact factor: 1.436. Q3
Kiran NS, Senthilkumar Rajagopal. Neuroinflammation – The Role of Heteroreceptor Complexes. Exploration of Neuroprotective Therapy. 2025; 5: 1004105. Impact factor: 2.81. Q3
Nitya Mankal, Nabanita Mandal, Senthilkumar Rajagopal. Stability of antioxidative, peroxidative, and stress genes of food materials in different packaging materials at refrigerated condition. Food Nutrition Chemistry. 2025; 2(3): 289. Impact factor: 1.21. Q4
Ashmitha Reddy, Yogitha N Sagar, Nitya Mankal, Joice K Joseph, Panagal Mani, Senthilkumar Rajagopal. Comprehensive review on psychobiotics: The next-generation microbial biomedicine and biotherapeutics. Acta Scientific: Microbiology. 2025; 8(1):55-65. Impact factor: 1.416. Q4
Upasana Sarma, M Enamul Hoque, Aswani T, Nethravathy V, Senthilkumar Rajagopal. Microalgae in removing heavy metals – An advanced technology for urban wastewater treatment. Journal of Hazardous Materials Advances. 2024; 15; 100444. Impact factor: 7.7. Q1
Renuka Ravinath, Yogitha N Sagar, Nitya Mankal, Senthilkumar Rajagopal. micro RNA - The Promising Molecular Tool for Engineering Stress Resistance in Crop Plants. Russian Journal of Plant Physiology. 2024; 71:115-124. Impact factor: 1.419. Q2
Srinivasan Palaniselvam, Ranjitha Vijayanand, Varsha Selvachandhran, Sarulatha Manase, Senthilkumar Rajagopal, Saravanan Ramachandran. Structural characterization and toxicity effect of nano-carboxymethyl chitosan from Doryteuthis sibogae in zebrafish model. Biomass Conversion and Bio refinery. 2023; 14(20): 25123-25132. Impact factor: 4.05. Q2
Samer Shamshad, Samikshya Panda, Senthilkumar Rajagopal. Current trends and advances of quorum sensing inhibitors and their biotechnological applications. Indian Journal of Biochemistry and Biophysics. 2023; 60:255-280. Impact factor: 1.91. Q3
Senthilkumar Rajagopal. Modulatory action of voltage gated ion channels in inflammation and inflammatory pain. The Open Journal of Neurology. 2023; 17: 1-10. Impact factor: 1.93. Q4
Manisha Sonthalia, Bhramar Sinha Roy, Divya Chandrawanshi, Goutham V. Ganesh, Ravichandran Jayasuriya, Sundhar Mohandas, Senthilkumar Rajagopal, Kunka Mohanram Ramkumar. Histone deacetylase inhibitors as antidiabetic agents: Advances and opportunities. European Journal of Pharmacology. 2022; 935; 175238. Impact factor: 5.41. Q1
Arya Aji, Senthilkumar Rajagopal, Saravanan Ramachandran, and Rajadurai Murugan. Extraction of Chitin and Chitosan from Marine Waste and its Applications on Food and Agriculture Products. Asian Journal of Biological Sciences. 2022; 15 (6): 271-279. Q2
Vidya M, Senthilkumar Rajagopal. Silk fibroin: Biomedical applications in skin regeneration and wound healing. International Journal of Polymer Science. Volume. 2021. Article ID 9069924: 1-10. Q1
B. Manimegalai, GV. Swarnalatha, Veerappan Ramanathan, Senthilkumar Rajagopal. Effect of Achyranthes Aspera (Linn) seeds on membrane-bound ATPases in selected tissues of rats fed with high doses of fructose. Current Trends in Biotechnology and Pharmacy. 2021; 15 (4): 371-377. Q3
Shubham Singh, Supraj Raja Sangam, Senthilkumar Rajagopal. Regulation of Dietary Amino Acids and Voltage-Gated Calcium Channels in Autism Spectrum Disorder. Advances in Neurobiology. 2020; 24: 647-660. Q2
Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review. Razak MA, Begum PS, Viswanath B, Rajagopal S. Oxid Med Cell Longev. 2017;2017:1716701. doi: 10.1155/2017/1716701. Epub 2017 Mar 1. PMID: 28337245
Inflammatory Mediators in Obesity. Kumar DP, Koka S, Li C, Rajagopal S. Mediators Inflamm. 2019 Jul 31;2019:9481819. doi: 10.1155/2019/9481819. eCollection 2019. PMID: 31485196
Regulation of Dietary Amino Acids and Voltage-Gated Calcium Channels in Autism Spectrum Disorder. Singh S, Sangam SR, Senthilkumar R. Adv Neurobiol. 2020;24:647-660. doi: 10.1007/978-3-030-30402- 7_24. PMID: 32006378
Editorial: Regulatory Action of Calcium Channels in Pain Pathway. Rajagopal S, Murugan S, Kumar DP, Kesturu GS, Arul AB. Front Cell Neurosci. 2021 May 31;15:701105. doi: 10.3389/fncel.2021.701105. eCollection 2021. PMID: 34135735
Modulatory Effects of Dietary Amino Acids on Neurodegenerative Diseases. Rajagopal S, Sangam SR, Singh S, Joginapally VR. Adv Neurobiol. 2016;12:401-14. doi: 10.1007/978-3-319-28383-8_22. PMID: 27651266
Stimulatory and inhibitory effects of PKC isozymes are mediated by serine/threonine PKC sites of the Cav2.3α1 subunits. Rajagopal S, Burton BK, Fields BL, El IO, Kamatchi GL. Arch Biochem Biophys. 2017 May 1;621:24-30. doi: 10.1016/j.abb.2017.04.002. Epub 2017 Apr 5. PMID: 28389298
Inhibition of RhoA-dependent pathway and contraction by endogenous hydrogen sulfide in rabbit gastric smooth muscle cells. Nalli AD, Rajagopal S, Mahavadi S, Grider JR, Murthy KS. Am J Physiol Cell Physiol. 2015 Mar 15;308(6):C485-95. doi: 10.1152/ajpcell.00280.2014. Epub 2015 Jan 7. PMID: 25567809
Contribution of protein kinase Cα in the stimulation of insulin by the down-regulation of Cavβ subunits. Rajagopal S, Fields BL, Kamatchi GL. Endocrine. 2014 Nov;47(2):463-71. doi: 10.1007/s12020-013-0149- y. Epub 2014 Jan 23. PMID: 24452871
Differential regulation of muscarinic M2 and M3 receptor signaling in gastrointestinal smooth muscle by caveolin-1. Bhattacharya S, Mahavadi S, Al-Shboul O, Rajagopal S, Grider JR, Murthy KS. Am J Physiol Cell Physiol. 2013 Aug 1;305(3):C334-47. doi: 10.1152/ajpcell.00334.2012. Epub 2013 Jun 19. PMID: 23784544
10 Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells. Kumar DP, Rajagopal S, Mahavadi S, Mirshahi F, Grider JR, Murthy KS, Sanyal AJ. Biochem Biophys Res Commun. 2012 Oct 26;427(3):600-5. doi: 10.1016/j.bbrc.2012.09.104. Epub 2012 Sep 27. PMID: 23022524
Effect of glycine on tissue fatty acid composition in an experimental model of alcohol-induced hepatotoxicity. Senthilkumar R, Nalini N. Clin Exp Pharmacol Physiol. 2004 Jul;31(7):456-61. doi: 10.1111/j.1440-1681.2004.04021.x. PMID: 15236634
Glycine prevents hepatic fibrosis by preventing the accumulation of collagen in rats with alcoholic liver injury. Senthilkumar R, Nalini N. Pol J Pharmacol. 2004 Jan-Feb;56(1):121-8. PMID: 15047986
Glycine modulates hepatic lipid accumulation in alcohol-induced liver injury. Senthilkumar R, Viswanathan P, Nalini N. Pol J Pharmacol. 2003 Jul-Aug;55(4):603-11. PMID: 14581719
Protein kinase C isozyme-specific potentiation of expressed Ca v 2.3 currents by acetyl-beta- methylcholine and phorbol-12-myristate, 13-acetate. Rajagopal S, Fang H, Patanavanich S, Sando JJ, Kamatchi GL. Brain Res. 2008 May 19;1210:1-10. doi: 10.1016/j.brainres.2008.03.017. Epub 2008 Mar 20. PMID: 18420182
The potential beneficial effect of glycine on the carbohydrate moieties of glycoproteins in an exper- imental model of alcohol-induced hepatotoxicity. Senthilkumar R, Nalini N. J Med Food. 2004 Spring;7(1):108-13. doi: 10.1089/109662004322984798. PMID: 15117562
Cytokine-induced S-nitrosylation of soluble guanylyl cyclase and expression of phosphodiesterase 1A contribute to dysfunction of longitudinal smooth muscle relaxation. Rajagopal S, Nalli AD, Kumar DP, Bhattacharya S, Hu W, Mahavadi S, Grider JR, Murthy KS. J Pharmacol Exp Ther. 2015 o Mar;352(3):509-18. doi: 10.1124/jpet.114.221929. Epub 2014 Dec 30. PMID: 2555019
Inhibitory role of Ser-425 of the alpha1 2.2 subunit in the enhancement of Cav 2.2 currents by phor- bol-12-myristate, 13-acetate. Fang H, Patanavanich S, Rajagopal S, Yi X, Gill MS, Sando JJ, Ka- matchi GL. J Biol Chem. 2006 Jul 21;281(29):20011-7. doi: 10.1074/jbc.M601776200. Epub 2006 May 16. PMID: 16704976
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway. Rajagopal S, Kumar DP, Mahavadi S, Bhattacharya S, Zhou R, Corvera CU, Bunnett NW, Grider JR, Murthy KS. Am J Phys- iol Gastrointest Liver Physiol. 2013 Mar 1;304(5):G527-35. doi: 10.1152/ajpgi.00388.2012. Epub 2012 Dec 28. PMID: 23275618
Formalin-induced short- and long-term modulation of Cav currents expressed in Xenopus oocytes: an in vitro cellular model for formalin-induced pain. Rajagopal S, Fang H, Lynch C 3rd, Kamatchi GL. Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):338-47. doi: 10.1111/j.1742- 7843.2009.00496.x. Epub 2009 Dec 22. PMID: 20030632
Release of GLP-1 and PYY in response to the activation of G protein-coupled bile acid receptor TGR5 is mediated by Epac/PLC-ε pathway and modulated by endogenous H2S. Bala V, Rajagopal S, Kumar DP, Nalli AD, Mahavadi S, Sanyal AJ, Grider JR, Murthy KS. Front Physiol. 2014 Nov 3;5:420. doi: 10.3389/fphys.2014.00420. eCollection 2014. PMID: 25404917
Hypolipidemic effect of Cuminum cyminum L. on alloxan-induced diabetic rats. Dhandapani S, Subramanian VR, Rajagopal S, Namasivayam N. Pharmacol Res. 2002 Sep;46(3):251-5. doi: 10.1016/s1043-6618(02)00131-7. PMID: 12220968

Other Publications: 19

B. Manimegalai, GV. Swarnalatha, Veerappan Ramanathan, Senthilkumar Rajagopal. Effect of Achyranthes Aspera (Linn) seeds on membrane-bound ATPases in selected tissues of rats fed with high doses of fructose. Current Trends in Biotechnology and Pharmacy. 2021; 15 (4): 371-377.
Veerappan Ramanathan, Swarnalatha GV, Senthilkumar Rajagopal. Suppression of hepatic oxida- tive events and regulation of eNOS expression in the liver by chrysin in high fructose-fed rats. Chet- tinad Health City Medical Journal. 2021; 10 (1): 1-7.
Veerappan Ramanathan, GV Swarnalatha, B. Manimegalai, A. Dominic Amalraj, Senthilkumar Rajagopal. Chrysin pretreatment improves mitochondrial enzymes and angiotensin converting en- zymes in L-NAME induced hypertensive rats. Current Trends in Biotechnology and Pharmacy. 2020; 14 (3): 327-339.
Pathan Shajahan Begum, Meerza Abdul Razak, Senthilkumar Rajagopal, Vakita Venkataratnam- ma. Antiviral Effects Of Probiotic Bacteria Isolated From Fresh Water Fishes Against White Spot Syndrome Virus. Journal of Emerging Technologies and Innovative Research. 2018; 5(11): 76-91.
Pathan Shajahan Begum, Meerza Abdul Razak, Senthilkumar Rajagopal, V. Venkataratnamma. Effect of probiotic bacteria on shrimp pond ecosystem and their influence on growth and survival of Litopenaeus Vannamei. International Journal of Scientific Research in Sci- ence, Engineering and Technology. 2018; 4(4): 1158-1165.
Syeda Kulsum, G. Vidya Sagar, R.Senthilkumar, Syed Mohammed Kazim. Bio-analytical method development and validation for metformin and canagliflozin by RP-HPLC. World Journal of Phar- macy and Pharmaceutical Science. 2017; 6(12): 371-381.
Veerappan Ramanathan, Senthilkumar Rajagopal. Chrysin ameliorates the lipid profiles in Nω- nitro-l-arginine-methylester-induced hypertensive rats. American Journal of Biochemistry and Mo- lecular Biology; 2016; 6: 60-66.
MA. Razak, S. Rajagopal, PA. Basha, DM. Rao, PS. Begum, D. Rajakumari, B. Viswanath. En- hancing the activity aspartate kinase for an overproduction of L-lysine by Corynebacterium glu- tamicum. American Journal of Biochemistry and Molecular Biology; 2016; 6:33-44.
Senthilkumar Rajagopal, Blanche L. Fields and Ganesan L. Kamatchi. Contribution of Protein Kinase C Isozyme in the Stimulation of Insulin Secretion by the Inhibition of Cavβ subunits. En- docrine; 2014; 47(2):463-471.
Vanitha Bala, Senthilkumar Rajagopal, Divya P. Kumar, Sunila Mahavadi, Ruizhe Zhou, Zachary L. Bradley, Nigel W Bunnett, Carlos U. Corvera, Johan Auwerx, John R. Grider, Arun J. Sanyal, Karnam S. Murthy. Hydrogen Sulfide (H2S) Inhibits Bile Acid Receptor TGR5-Mediated GLP-1 Release from Enteroendrocrine Cells: Possible Involvement of H2S in Altered Glucose Metabolism in Diabetes. Gastroenterology. 2012; 142 (5): S-50.
Vanitha Bala, Sunila Mahavadi, Senthilkumar Rajagopal, Ruizhe Zhou, John F. Kuemmerle, Arun J. Sanyal, Karnam S. Murthy. Bile Acid-Induced Stimulation of ERK1/2 Activity, GLP-1 and PYY Release in Enteroendocrine Cells are mediated by the Activation of Epac/PLC-ɛ Signaling Pathway via GS-Coupled TGR5. Gastroenterology. 2011; 140 (5): S-147.
Senthilkumar Rajagopal, Othman Al-Shboul, Sunila Mahavadi, John F Kuemmerle, Karnam S Murthy. Expression and Function of Bile Acid Receptor TGR5 in Gastrointestinal Smooth Muscle. FASEB Journal, 2011; 25: 1069.5.
Othman Al-Shboul, Sunila Mahavadi, Senthilkumar Rajagopal, Ruizhe Zhou, Karnam S Murthy. Differences in the Expression of VPAC2 Receptors and Adenylyl Cyclase V/VI and VIP-Induced cAMP Generation in Phasic and Tonic Smooth Muscles. FASEB Journal, 2011; 25: 1069.7.
Senthilkumar Rajagopal, Hongyu Fang, Carl Lynch III, Ganesan Kamatchi L. Formalin -induced –short and long-term modulation of Cav currents expressed in Xenopus oocytes: An in vitro cellular model for formalin –induced pain. Basic and Clinical Pharmacology and Toxicology. 2010; 106: 338-347.
M.Sengottuvelan, R.Senthilkumar, N.Nalini. Modulatory influence of dietary resveratrol during different phases of a one, 2-dimethylhydrazine induced mucosal lipid-peroxidation, antioxidant sta- tus and aberrant crypt foci development in rat colon carcinogenesis. Biochimica Biophysica Acta. 2006; 1760: 1175-1183.
R. Senthilkumar, N. Nalini. The potential beneficial effect of glycine on the carbohydrate moieties of glycoproteins in an experimental model of alcohol induced hepatotoxicity. Journal of Medicinal Food. 2004, Spring; 7(1): 108-113.
R. Senthilkumar, P. Viswanathan, N. Nalini. Effect of glycine on oxidative stress in rats with alco- hol induced liver injury. Die Pharmazie. 2004; 59(1): 55-60.
R.Senthilkumar, M.Sengottuvelan, N. Nalini. Protective effect of glycine supplementation on the levels of lipid peroxidation and antioxidant enzymes in the erythrocyte of rats with alcohol induced liver injury. Cell Biochemistry and Function. 2004; 22(2): 123-128.
Pathan Shajahan Begum, Gujjula Madhavi, Senthilkumar Rajagopal, Buddolla Viswanath, Meer- za Abdul Razak, V. Venkataratnamma. Probiotics as functional foods: potential effects on human health and neurological diseases. International Journal of Nutrition, Pharmacology, Neurological Diseases. 2017; 7:23-33.
Senthilkumar Rajagopal, Shubham Singh, Supraj Raja Sangam. Contribution of Protein Kinase C (PKC) in the modulation of Voltage gated Calcium Channels. Journal of Pharmaceutical and Bio- medical Sciences. 2015; 5(4):351-354.

Patents Copyrights

2 Filed

Patents Granted: 1

Books Published

UG / PG Projects

Research Project

Research Summary: A novel membrane-bound G protein-coupled receptor, TGR5, is involved in modulating gastrointestinal functions such as secretion and motility. TGR5 receptor regulates glucose and energy homeostasis and maintains gastrointestinal integrity. Bile acids, apart from aiding nutrient absorption, are important signaling molecules with paracrine and endocrine functions. They act as ligands for the TGR5 receptor, influencing secretion, motility, and glucose regulation through cAMP/PKA, Ca²⁺/PKC, MAP kinase, and tyrosine kinase pathways. Understanding the molecular mechanisms underlying TGR5-induced functions has therapeutic potential for controlling weight gain and improving glucose homeostasis. Dr. Senthilkumar’s research demonstrates that in gastric smooth muscle, TGR5 receptors are coupled to the Gαs/cAMP pathway, where activation leads to muscle relaxation via PKA-dependent phosphorylation of RhoA and Epac-dependent stimulation of Rap1.

GPCR signalling in inflammation