Specialization
Cancer Biology
Qualification
PhD (Sri Krishnadevaraya University), Postdoc (University of Chicago, USA
Teaching Experience
18 years
Awards & Recognition
- Best Researcher Award - REVA University - 2025
- Research Excellence Award - REVA University - 2023
- Ramanujan Fellowship Award- 2015
- DST-SERB - Young Scientist Award - 2014
- Member in Institute for Integrative Physiology, University of Chicago, 2011- 2014.
- Travel award to attend Young Investigator Meeting held at Hyderabad-2014 (USA- India).
International Visits: - USA, South Africa
Linkedin
Orcid ID
0000-0002-4441-0859
Vidwan ID/Profile URL
https://vidwan.inflibnet.ac.in/profile/230027
Scopus ID/Google Scholar ID
https://scholar.google.com/citations?hl=en&user=wZcBfuQAAAAJ
Funded Project (amount sanctioned)
| Sl. No |
Name of the Funding Agency |
Type (Government/Non-Government) |
Department |
Year of Award |
Funds Provided (INR in lakhs) |
Year of Sanction |
Status |
| 1 |
DST-SERB |
Government |
Biochemistry |
2014 |
32 lakhs |
2014 |
Completed |
| 2 |
DST-SERB |
Government |
Biochemistry |
2015 |
89 lakhs |
2016 |
Completed |
| 3 |
DST |
Government |
Biotechnology |
2023 |
411 lakhs |
2022 |
On-going |
PhDs Guided/PhDs Guiding
5
Publications In Refereed Journals
Key Publications (Only Q1 & Q2 rated):- 47
- Dalli Kumari, Sadhanala Trimurthulu, Gouthami K, Reddy VD, Aravinda T, Guru raja N, Nagendra G, Synthesis of Enduracididine free linear Teixobactin analogs: Molecular Docking, DFT calculations and its Antimicrobial activities, Bacterial cell wall lysis and Glucose assay. Current Medicinal Chemistry, 2025, In Press Q2, IF-3.5.
- Kuruvalli Gouthami, Padmavathi Pannuru, P.C. Nagajyothi, Deepika Shekhawat, Ayantika Santra, Subhasish Maity, Venkata Prasad Surtineni, Selvam Arjunan, Vaddi Damodara Reddy, Jaesool Shim. Comprehensive review on alcohol-induced protein modification in hepatic mitochondrial membranes and their functional implications. Molecular Biology Reports, 2025, In Press Q2, IF-2.8.
- Dalli Kumari, Nagendra G Gouthami K, Reddy VD, A computational strategy to identify Hub genes in pathway analysis of gamma toco-trienol treated MCF-7 cells and Molecular Docking study using selected phytochemicals as therapeutic agents. Current Medicinal Chemistry, 2025, In Press Q2, IF-3.5.
- P.C.Nagajyothia, Kuruvalli Gouthami, K. Pavani, Vaddi Damodara Reddy, Jaesool Shima. NiTiO3 nanostructures for enhanced electrocatalytic urea oxidation under alkaline conditions. Inorganic Chemistry Communications. 2025, 182,115474, Q1 IF:5.4
- Chethan Kumar Narayanaswamy, Gouthami Kuruvalli, Subhasish Maity, Althaf Hussain Shaik, Hymavathi Reddyvari, Vaddi Damodara Reddy, Guruprasad NM. Fortified Food with Withania somnifera modulates glucose metabolism in STZ-induced hyperglycemia in rats. Biotechnology and Applied Biochemistry. 2025 – In Press- Q2, IF-2.7
- Deepika Shekhawat, Gouthami K, Ayantika Santra, Subhasish Maity, P.C. Nagajyothi*, Jaesool Shim*, Reddy VD*. A Comprehensive Review of Antimicrobial Drugs: Mechanisms of Action and Specific Targets in Microorganisms. Journal of Basic Microbiology. 2025, In Press Q2, IF-3.5
- P.C. Nagajyothi, Kuruvalli Gouthami, Subhasish Maity, K. Pavani, Clement Okraku Tettey , Vaddi Damodara Reddy, Jaesool Shim. Antibacterial and anticancer activity of Ag-CeO2 nanocomposite. Journal of Cluster Science. 2025; 36, 146. Q2 IF: 2.8
- R Sreekanth, J Pattar, VD Reddy, K Gouthami. Exploring Mn4+ dopant concentration to differentiate selective antimicrobial activity of Mn4+/MgO nanocomposites: Insights into binding affinity. Inorganic Chemistry Communications. 2025. 177; 114336. Q1 – IF-4.4
- Sowjanya Bandlapalli, Reddi Mohan Naidu Kalla, Venakta Narayana Palakollu, Gouthami Kuruvalli, Vaddi Damodara Reddy, Kholood A. Dahlous, Jaewoong Lee. Synthesis, anti-microbial and docking studies of functionalized chromenyl phosphonates using ionic liquid catalyst. Molecular Diversity – 2025, 29, 1655-67 IF:3.9
- Dalli Kumari, Vaishnavi Raosaheb Vhanmane, Gouthami Kuruvalli,Vaddi Damodara Reddy, Nagendra Govindappa, 2-DPC mediated effective synthesis of peptide conjugates, their antifungal and antibacterial properties. Chemistry Select, 2024; 9 (31), e202402123. IF -1.9
- Kanu VK, Pulakuntla S, Karuvalli G, Aramgam S, Marthadu SB, Pannuru P, Hebbani AV, Badri KR, Reddy VD. Anti-Atherogenic Role of Green Tea in South Indian smokers Journal of Ethnopharmacology.2024. Volume 332, 118298 IF:5.4
- Mallikarjunaswamy A M M, Gouthami Kuruvalli, Khajamohiddin Syed and Vaddi Damodara Reddy, Vipin Nair. An efficient and ecofriendly procedure for electrophilic thiocyanation of anilines and 1-(substituted benzylidene)-2-phenylhydrazines. Chemistry, 2024-6(3), 476-488; IF:2.1
- Guru Prasad Venkatesh, Gouthami Kuruvalli, Khajamohiddin Syed and Vaddi Damodara Reddy. An Updated Review on Probiotic Production and Applications. Gastroenterology Insights. 2024, 15, 221–236. Q2-IF:2.9.
- Sreekanth R, S. Naveen Kumar, Madhusudhan Reddy M. Jayadev Pattar and Damodara Reddy V. Investigating the effect of acidic and basic precipitation on the antibacterial activity of ZnO nanoparticles against Gram-negative and Gram-positive bacteria. Journal of Materials Chemistry B, 2024, 12, 2180–2196, Q1-IF:7.0
- Lonappan DK, Gouthami Kuruvalli G, Shaik AH, Hebbani AV, Reddyvari H, Reddy VD, Vadamalai V. Alcohol induced hormonal and metabolic alterations in plasma and erythrocytes - A gender based study. Toxicology Mechanisms and Methods. 2024, 34 (4), 350-358, Q2-IF:3.2
- Swetha Pulakuntla, Khajamohiddin Syed and Vaddi Damodara Reddy. Analysis of somatic mutations in the TCGA-LIHC whole exome sequence to identify the neoantigen for immunotherapy in hepatocellular carcinoma. Current Issues in Molecular Biology. 2024. 46(1), 106-120. Q2- IF: 3.1
- Maity S, Santra A, Hebbani AV, Pulakuntla S, Chatterjee A, Badri KR, Reddy VD. Targeting cytokine storm as the potential anti-viral therapy: Implications in regulating SARS-CoV-2 pathogenicity. Gene (2023). Volume 881, 25, 147612, Q2 IF:3.5
- Pulakuntla S, Hebbani AV, Pannuru P, Aramgam S, Badri KR, Reddy VD*. COVID-19: Comprehensive Review on Mutations and Current Vaccines. Archives of Microbiology- 2022; 204(1):1-17. - Q2 IF:2.66
- Gurumurthy, D.M., Bilal, M., Nadda, A.K. Reddy VD, Saratale GD, Guzik U, Ferreira RFL, Gupta SK, Savanur MA, Mulla SI. Evaluation of cell wall-associated direct extracellular electron transfer in thermophilic Geobacillus sp. 3 Biotech 11, 383 (2021). IF: 2.89 - Q2
- Mulla SI Shah A, Tyagi S, Saratale GD, Guzik U, Hu A, Sreevathsa R, Reddy VD, Rai V. A comprehensive review on influence of light on signaling cross-talk and molecular communication against phyto-microbiome interactions. Critical Reviews in Biotechnology, 2021, 41 (3), 370-393– IF: 9.06 – Q1
- Hebbani AV, Reddy VD, Asha BM, Nallanchakravarthula V. Protective effect of Terminalia arjuna against alcohol induced oxidative damage in rat erythrocyte membranes. Journal of Ayurveda and Integrative Medicine. 2021, 12, 330-339. Q2 IF: 2.4
- Bagewadi ZK., V Dsouza, SI. Mulla, SH. Deshpande, UM. Muddapur, DA. Yaraguppi, VD Reddy, JS. Bhavikatti, SS. More. Structural and Functional Characterization of Bacterial Cellulose from Enterobacter hormaechei subsp. steigerwaltii strain ZKE7, Cellulose, 2020, 27, 9181–9199 - IF:6.12 - Q1
- Vaddi DR, Ning Wang, Makarenko V, Khan SA, Yuan G and Prabhakar NR. Nanduri J. Hypoxia induced human ether-a-go-go-related (hERG) protein trafficking defect linked to cell cycle arrest in neuroblastoma cells. PLoS One, 2019,14(4), e0215905. IF:3.75 - Q1
- Padmavathi P, Raghu PS, Reddy VD*, Bulle S, Marthadu S, Maturu P and Varadacharyulu N.C. Chronic cigarette smoking-induced oxidative/nitrosative stress in human erythrocytes and platelets. Molecular and Cellular Toxicology, 2018; 14(1): 227-34. IF: 1.7 - Q2
- Reddy VD*, Padmavathi P, Bulle S, Hebbani AV, Marthadu SB, Venugopalacharyulu N.Ch, Maturu P and Varadacharyulu NC. Association between alcohol-induced oxidative stress and membrane properties in synaptosomes: A protective role of vitamin E. Neurotoxicology and Teratology 2017; 63: 60-65. IF: 2.9 -Q2
- Krushna GSS, Shivaranjani VL, Umamaheswari J, Hussain SA, Kareem MA, Reddy VD, Ali D, Lokhande KB, Swamy KV and Kodidhela LD. In vivo and molecular docking studies using whole extract and phytocompounds of Aegle marmelos fruit protective effects against Isoproterenol-induced Myocardial infarction in rats. Biomedicine & Pharmacotherapy 2017, 91; 880-889 IF: 7.5 – Q1
- Saradamma B, Reddy VD, Padmavathi P, Paramahamsa M, Pavan Kumar P and Varadacharyulu N. Association between alcohol-induced erythrocyte membrane alterations and hemolysis in chronic alcoholics. Journal of Clinical Biochemistry and Nutrition, 2017; 60(1): 63-69. IF: 2.4 - Q2
- Bulle S, Reddy VD, Hebbani AV, Padmavathi P, Challa C, Puvvada PK, Repalle E, Nayakanti D, Aluganti Narasimhulu C, Nallanchakravarthula V. Nephro-protective action of P. santalinus against alcohol-induced biochemical alterations and oxidative damage in rats. Biomedicine & Pharmacotherapy. 2016; 84: 740-746. IF: 7.5 - Q1
- Saradamma B, Reddy VD, Padmavathi P, Paramahamsa M and Varadacharyulu N. Modulatory role of Pterocarpus santalinus against alcohol-induced liver oxidative/nitrosative damage in rats. Biomedicine & Pharmacotherapy, 2016; 83: 1057-1063. IF: 7.5 - Q1
- Nanduri J, Reddy VD, Khan SA, Wang N, Makarenko V, Semenza GL and Prabhakar NR. HIF-1α activation by intermittent hypoxia requires NADPH oxidase stimulation by xanthine oxidase. PLos One -2015, 10(3): e0119762. IF: 3.7 - Q1
- Peng YJ, Yuan G, Khan SA, Nanduri J, Reddy VD, Vasavda C, Kumar G, Semenza GL and Prabhakar NR. Regulation of Hypoxia –inducible factor –α isoforms and redox state by carotid body neural activity in rats. Journal of Physiology. 2014, 592(17): 3841-3858. IF: 5.5 - Q1
- Reddy VD, Padmavathi P, Hymavathi R, Paramahamsa M, Varadacharyulu NC. Alcohol-induced oxidative stress in rat liver microsomes: Protective effect of Emblica officinalis. Pathophysiology 2014; 21(2): 153-159– Q2
- Yuan G*, Peng YJ*, Reddy VD*, Makarenko V*, Nanduri J, Khan SA, Garcia JA, Kumar G, Semenza GL and Prabhakar NR. Mutual Antagonism between hypoxia inducible factors 1α and 2α regulates O2 sensing and cardio-respiratory homeostasis. PNAS (USA). 2013, 110 (19); E1788-E1796 (*equal 1st author). IF: 12.77 - Q1
- Nanduri J, Vaddi DR, Ning Wang, Makarenko V, Khan SA, Yuan G and Prabhakar NR. Xanthine oxidase mediates Hypoxia-inducible factor-2α degradation by Intermittent Hypoxia. PLoS One. 2013; 8(10): e75838. IF: 3.7 - Q1
- Reddy VD, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu NC. Alcohol-induced oxidative/nitrosative stress alters brain mitochondrial membrane properties Molecular and Cellular Biochemistry 2013; 375(1-2): 39-47. IF: 4.3 – Q1
- Maturu P, Reddy VD, Padmavathi P, Varadacharyulu NC. Modification of erythrocyte membrane proteins, enzymes and transport mechanisms in chronic alcoholics: An in vivo and in vitro study - Alcohol & Alcoholism 2013; 48(6): 679-686. IF: 2.8 - Q2
- Nanduri J, Makarenko V, Reddy VD, Yuan G, Pawar A, Ning Wang, Khan SA, Zhang X, Kinsman B, Peng YJ, Kumar GK, Fox A, Godley L, Semenza GL, Prabhakar NR. Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis. PNAS (USA) 2012;109: 2515-2520. IF: 12.77 – Q1
- Saayi Krushna G, Mohammed Abdul Kareem, Reddy VD, Padmavathi P, Sheik Althaf Hussain and Lakshmi Devi K. Aegle marmelos Fruit Extract attenuates Isoproterenol-Induced Myocardial Damage in Rats. Journal of Clinical Biochemistry and Nutrition 2012; 50: 199-204. IF: 2.4 - Q2
- Peng YJ, Nanduri J, Shakil A Khan, Yuan G, Wang N, Kinsman B, Vaddi DR, Kumar GK, Garcia JA, Semenza GL, Prabhakar NR. HIF-2α Heterozygous-Null Mice Exhibit Exaggerated Carotid Body Sensitivity to Hypoxia, Breathing Instability, and Hypertension. PNAS (USA) 2011; 108: 3065-3070. IF: 12.77 – Q1
- Padmavathi P, Reddy VD, Varadacharyulu NC. Increased Red blood cell Antioxidant status renders protection against smoking induced hemolysis in moderate cigarette smokers. Human & Experimental Toxicology 2011; 30: 1475-1481. IF: 2.8 – Q2
- Padmavathi P, Reddy VD, Paramahamsa M, Varadacharyulu NC. Smoking-induced alterations in platelet membrane fluidity and Na(+)/K(+)-ATPase activity in chronic cigarette smokers. Journal of Atherosclerosis and Thrombosis 2010; 17: 619-627 IF: 4.4 – Q2
- Maturu P, Reddy VD, Padmavathi P, Varadacharyulu NC. Alterations in erythrocyte membrane fluidity and Na(+)/K(+)-ATPase activity in chronic alcoholics. Molecular and Cellular Biochemistry 2010; 339: 35-42. IF: 4.3 – Q1
- Padmavathi P, Reddy VD, Kavitha G, Maturu P, Varadacharyulu NC. Chronic cigarette smoking alters erythrocyte membrane lipid composition and properties in male human volunteers. Nitric oxide 2010; 23:181–186. IF: 3.9– Q2
- Kavitha G, Reddy VD, Padmavathi P, Varadacharyulu NC. Association between plasma glucose and glycoproteins in alcoholic smokers compared to alcoholics and teetotalers. Diabetes & Metabolic syndrome: Clinical Research and Reviews 2010; 4: 155-159. – Q2 IF: 10
- Reddy VD, Padmavathi P, Varadacharyulu NC. Emblica officinalis protects against alcohol- induced liver mitochondrial dysfunction in rats. Journal of Medicinal Food 2009; 12: 327-333. IF: 2.4 – Q2
- Reddy VD, Padmavathi P, Paramahamsa M, Varadacharyulu NC. Modulatory role of Emblica officinalis on alcohol induced biochemical and biophysical changes in rat erythrocyte membranes. Food & Chemical Toxicology 2009; 47: 1958-1963. IF: 4.3 – Q1
- Padmavathi P, Reddy VD, Narendra M, Varadacharyulu NC. Bidis – hand-rolled, Indian cigarettes: induced biochemical changes in plasma and red cell membranes of human male volunteers. Clinical Biochemistry 2009; 42: 1041-1045. IF: 2.8 – Q2
- Kavitha G, Reddy VD, Paramahamsa M, Akthar PMd, Varadacharyulu NC. Role of nitric oxide in alcohol induced changes in lipid profile of moderate and heavy alcoholics. Alcohol 2008; 42: 47-53. IF: 2.3 – Q2
Other Publications: 44
- A, Madhusudhana Reddy MB, Nagarajaiah H, Damodara Reddy V, REVA University. Synthesis Characterization and Molecular Docking Studies of a Series of Fluorinated 2-Amino Pyrimidines, Fluor Mubeenainated Pyrazoles and Fluorinated Isoxazoles as Possible Anti-Cancer Agents. Application Number: 202341059160, Date published: 20/10/2023.
- Gouthami Kuruvalli, Vaddi Damodara Reddy, Padmavathi Pannuru, Subhasish Maity, A.M.M. Mallikarjunaswamy, REVA University. A fortified food with anti-diabetic activity. Application number 202441030167 dated published:19.04.2024.
- A.M.M. Mallikarjunaswamy, Gouthami Kuruvalli, Vaddi Damodara Reddy, Lakshmi B, REVA University. An efficient and eco-friendly procedure for electrophilic thiocyanation of anilines and 1-(substituted benzylidene)-2-phenyl hydrazines. Application number 202441054036 dated published:02.08.2024.
- A.M.M. Mallikarjunaswamy, Gouthami Kuruvalli, Vaddi Damodara Reddy, Lakshmi B, REVA University. Synthesis, Characterization, Antioxidant, in silico screening and Anti-cancer potential of substituted 2-(4-acetyl-5- methyl-1H-1,2,3-triazol-1-yl)-N-phenylacetamide Derivatives. Application number 202441070377. date published:18.09.2024.
- Nagendra G, Dalli Kumari, Gouthami K, Trimurthulu Sadhanala, Vaddi Damodara Reddy, Prashantha CN and REVA University. Synthesis of linear, Enduracididine free Teixobactin analog: In-silico screening and its biological activities. Application Number: 202441095015, date published:06.12.2024
- Gouthami Kuruvalli, Padmavathi Pannuru, Vaddi Damodara Reddy, A.M.M. Mallikarjunaswamy, REVA University . Exploring Camptotheca acuminata phytochemicals as potential linhibitors for throat cancer targets using in vitro and molecular docking studies. Application Number: 20541065404 date : 18.07.2025
- Sikandar I Mulla, Sathish Gayana, Raghupathi Anusha, Vaddi Damodara Reddy, Kuruvalli Gouthami, REVA University. Anti-diabetic, anti-microbial, anti-oxidant and amylase activity of Cassiatora. Application number 202541074321 dated published:5.08.2025.
Publications In Conferences
3
Research Project
Dr. Reddy's laboratory focus is to study the underlying molecular mechanisms in alcoholic liver disease (ALD) and the role of hypoxia inducible factor (HIF) 1 & 2α in the pathogenesis of ALD. Dr. Reddy's laboratory clearly demonstrated that initial two months alcohol consumption develops oxidative and nitrosative stress, which initiates different signaling pathways to onset ALD from simple steatosis fibrosis Cirrhosis/Cancer in the animal model. Our research focus on alcohol- induced HIFs activation and its role in the development of hepatic diseases including cancer.
Alcoholic Liver Disease