Dr. Vivek Keshri Assistant Professor

Specialization

Bioinformatics data analysis- antibiotic resistance genes identification, differential expression profiling, next-generation sequencing data analysis

Antibiotic resistance gene Beta-lactamase

Qualification

Ph.D. in Bioinformatics, Aix-Marseille University, France

Teaching Experience

Academic - 3.3 Years

Awards & Recognition

Awards & Recognitions:

• Editorial Role: Guest Editor, Antibiotics (MDPI) – Special Issue on “Tackling Multidrug-Resistant Bacteria with New Antimicrobial Strategies”.
• Journal Reviewer: BMC Microbiology, BMC Genomics, Interdisciplinary Perspectives on Infectious Diseases (Hindawi), PLOS ONE, Computational Biology and Bioinformatics, MDPI - Antibiotics, Gene & Protein in Disease (GPD), Frontiers in Endocrinology.
• Professional Association: Genetics Society of America, SSE (Society for the Study of Evolution), SORTEE (Society for Open, Reliable, and Transparent Ecology and Evolutionary Biology), Microbiology Society Early Career Microbiologist (ECM) Forum.

International Visits:

• Aix-Marseille University, France – for Ph.D.
• Shantou University Medical College, China – for Postdoctoral Research
• Adam Mickiewicz University, Poland – for Assistant Professor Position
• University of Lausanne, Switzerland – for ESEB Conference Participation

Orcid ID

https://orcid.org/0000-0001-5120-727X

Vidwan ID/Profile URL

https://vidwan.inflibnet.ac.in/profile/287572

Scopus ID/Google Scholar ID

57204070675

Publications In Refereed Journals

Key Publications (Only Q1 & Q2 rated):

• 2020, Life (MDPI) [PMID: 33202677] – Diene SM, Pinault L, Armstrong N, Azza S, Keshri V, Khelaifia S, Chabrière E, Caetano-Anolles G, Rolain JM, Pontarotti P, and Raoult D. Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea.
• 2020, International Journal of Molecular Sciences (MDPI) [PMID: 32872436] – Keshri V, Chabrière E, Pinault L, Colson P, Diene SM, Rolain JM, Raoult D and Pontarotti P. Promiscuous enzyme activity as a driver of allo and iso convergent evolution, lessons from the β-lactamases.
• 2019, Scientific Reports (Nature Publishing Group) [PMID: 31434986] – Diene SM, Pinault L, Keshri V, et al. Human metallo-β-lactamase enzymes degrade penicillin.
• 2019, Evolutionary Applications (Wiley Online Library) [PMID: 31548859] – Keshri V, Arbuckle K, Chabrol O, Rolain JM, Raoult D, Pontarotti P. The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid.
• 2019, Antimicrobial Agents and Chemotherapy (American Society of Microbiology) [PMID: 30783007] – Keshri V, Diene SM, Estienne A, Dardaillon J, Chabrol O, Tichit L, Rolain JM, Raoult D, Pontarotti P. An integrative database of β-lactamase: sequences, structures, functions, and phylogenetic trees.
• 2018, Genome Biology and Evolution (Oxford Academic) [PMID: 29672703] – Keshri V, Panda A, Levasseur A, Rolain JM, Pontarotti P, Raoult D. Phylogenomic analysis of β-lactamase in archaea and bacteria enables the identification of putative new members.

• Human metallo-β-lactamase enzymes degrade penicillin

  Diene SM, Pinault L, Keshri V, Armstrong N, Khelaifia S, Chabrière E, Caetano-Anolles G, Colson P, La Scola B, Rolain JM, Pontarotti P, Raoult D. Sci Rep. 2019 Aug 21;9(1):12173. doi: 10.1038/s41598-019-48723-y. PMID: 31434986; PMCID: PMC6704141.

• Promiscuous Enzyme Activity as a Driver of Allo and Iso Convergent Evolution, Lessons from the β-Lactamases

  Keshri V, Chabrière E, Pinault L, Colson P, Diene SM, Rolain JM, Raoult D, Pontarotti P. Int J Mol Sci. 2020 Aug 29;21(17):6260. doi: 10.3390/ijms21176260. PMID: 32872436; PMCID: PMC7504333.

• Dual RNase and β-lactamase Activity of a Single Enzyme Encoded in Archaea

  Diene SM, Pinault L, Armstrong N, Azza S, Keshri V, Khelaifia S, Chabrière E, Caetano-Anolles G, Rolain JM, Pontarotti P, Raoult D. Life (Basel). 2020 Nov 14;10(11):280. doi: 10.3390/life10110280. PMID: 33202677; PMCID: PMC7697635.

• Phylogenomic Analysis of β-Lactamase in Archaea and Bacteria Enables the Identification of Putative New Members.

  Keshri V, Panda A, Levasseur A, Rolain JM, Pontarotti P, Raoult D. Genome Biol Evol. 2018 Apr 1;10(4):1106-1114. doi: 10.1093/gbe/evy028. PMID: 29672703; PMCID: PMC5905574.

• The functional convergence of antibiotic resistance in β-lactamases is not conferred by a simple convergent substitution of amino acid.

  Keshri V, Arbuckle K, Chabrol O, Rolain JM, Raoult D, Pontarotti P. Evol Appl. 2019 Jul 18;12(9):1812-1822. doi: 10.1111/eva.12835. PMID: 31548859; PMCID: PMC6752183.

• An Integrative Database of β-Lactamase Enzymes: Sequences, Structures, Functions, and Phylogenetic Trees.

• Keshri V, Diene SM, Estienne A, Dardaillon J, Chabrol O, Tichit L, Rolain JM, Raoult D, Pontarotti P. Antimicrob Agents Chemother. 2019 Apr 25;63(5):e02319-18. doi: 10.1128/AAC.02319-18. Print 2019 May. PMID: 30783007

Other Publications:

• 2023, World Journal of Pharmaceutical Science and Research – Awari M, Keshri V. Potential Drug Target Identification in Brucella abortus by subtractive genomics approach.
• 2016, Current Research in Bioinformatics – Singh DP, Prabha R, Keshri V, and Abhilash PC. Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein from Burkholderia sp. using Computational Approaches.
• 2013, 3Biotech (Springer) [PMID: 28324466] – Keshri V, Singh DP, Prabha R, Rai A, and Sharma AK. Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv oryzae PXO99A pathogenic to rice.

• Structure Prediction and Binding Site Analysis of Hepatotoxic Microcystin-LR Degrading MlrC-Like Protein

  from Burkholderia sp. using Computational Approaches

  Singh DP, Prabha R, Keshri V, and Abhilash PC

  2016, Current Research in Bioinformatics

• Genome subtraction for the identification of potential antimicrobial targets in Xanthomonas oryzae pv

  oryzae PXO99A pathogenic to rice

  Keshri V, Singh DP, Prabha R, Rai A, and Sharma AK. 2013, 3Biotech (Springer) [PMID: 28324466]